Autoimmune Lymphoproliferative Syndrome


ALPS symptoms

Some things that are seen most often in people with ALPS include:
  • An enlarged spleen.
  • Enlarged lymph nodes, especially in the neck and underarms.
  • An enlarged liver.
  • Skin rashes.
  • Frequent nose bleeds.
  • Anemia (low blood counts).
  • An increase in certain types of white blood cells (including double-negative T cells).
  • An increased life-span of some white blood cells that are no longer needed.
  • An alteration in a gene.

=ALPS - What is it?
= ALPS is a rare disease that affects both children and adults. ALPS stands for Autoimmune LymphoProliferative (lim-fo-pro-lif'-er-a-tive) Syndrome. Each of these three words helps describe the main features of this condition. The word autoimmune (self-immune) identifies ALPS as a disease of the immune system. The tools used to fight germs turn against our own cells and cause problems. The word lymphoproliferative describes the unusually large numbers of white blood cells (called lymphocytes (lim'-fo-sites)) stored in the lymph nodes and spleens of people with ALPS. The word syndrome refers to the many common symptoms shared by ALPS patients.

  • ALPS develops in the early childhood years
  • ALPS is not contagious
  • There is a wide difference of severity in ALPS
  • ALPS, unlike other diseases, gets less severe over time